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Research Profile

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Xiling Shen

  • Xiling Shen
  • Dept: Electrical and Computer Engineering
  • Title: Assistant Professor
  • Address:
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Dr. Xiling Shen has been an assistant professor in the School of Electrical and Computer Engineering at Cornell University since 2009. He received his B.S. and M.S. degrees from Stanford University in 2001 and PhD degree from Stanford University in 2008. He also worked as an analog and wireless circuit designer at Barcelona Design and Texas Instruments between 2001 and 2004.

Research Interests

In the emerging field of Systems Biology, the Shen lab tries to tackle complex biological questions from a system engineering perspective rather than treating individual reactions in an isolated fashion. Of particular interest are how individual cells make decisions in heterogeneous populations to form tissues, and how such decisions making processes are subverted by diseases like cancer. The Shen lab studies colorectal cancer, intestinal stem cells, and tuberculosis tissue remodeling to answer some of the fundamental questions and to pursue clinical therapeutics.

Teaching Interests

Introduction to Systems and Synthetic Biology Electronics for Life Sciences

Selected Publications

  • Shen, Xiling, J. Collier, D. Dill, L. Shapiro, M. Horowitz, H. H. McAdams. 2008. "Architecture and Inherent Robustness of a Bacterial Cell-cycle Control System." Proc Natl Acad Sci U S A 105 (32): 11340-11345.
  • Shen, Xiling, J. M. Kahn, M. A. Horowitz. 2005. "Compensation for Multimode Fiber Dispersion by Adaptive Optics." Optics Letters 30 (22): 2985-7.
  • Bu, Pengcheng, Kai-Yuan Chen, Joyce Huan Chen, Lihua Wang, Jewell Walters, Yong Jun Shin, Julian P. Goerger, Jian Sun, Mavee Witherspoon, Nikolai Rakhilin, Jiahe Li, Herman Yang, Jeff Milsom, Sang Lee, Warren Zipfel, Moonsoo M. Jin, Zeynep H. Gumus, Steven M. Lipkin, Xiling Shen. 2013. "A MicroRNA miR-34a Regulated Bimodal Switch Targets Notch in Colon Cancer." Cell Stem Cell 12 (5): 602-615.
  • Shin, Y. J., K. Y. Chen, B. Hencey, S. Lipkin, A. H. Sayed, Xiling Shen. 2013. "Post-translational Regulation Enables Robust p53 Reglation." BMC Systems Biology 7 (83).
  • Bu, P., K. Y. Chen, S. M. Lipkin, Xiling Shen. 2013. "Asymmetric Division: A Marker for Cancer Stem Cells in Early Stage Tumors?." Oncotarget 4: 948.

Selected Awards and Honors

  • National Science Foundation Early CAREER Award (National Science Foundation) 2014
  • Mayfield Fellow, Technology Venture (Stanford University) 2000



  • MS (Electrical Engineering), Stanford Unversity, 2001
  • BS (Electrical Engineering), Stanford Unversity, 2001
  • Ph D (Electrical Engineering), Stanford University, 2008